Glycation – The third driver of aging

• Following oxidation and regenerative decline, glycation represents the third major biological driver of skin ageing;
• While oxidation damages the skin through free radical activity and regenerative decline slows the skin’s ability to repair and renew itself, glycation contributes to ageing by altering the skin’s structural proteins at a molecular level;
• Glycation is a biological process in which excess sugars bind to proteins such as collagen and elastin;
• This reaction forms harmful compounds known as Advanced Glycation End Products (A.G.E.s), which accumulate over time within the skin and body;
• As these compounds build up, they begin to stiffen, weaken, and deform collagen and elastin fibres—two of the most important structural proteins responsible for maintaining the skin’s firmness, elasticity, and resilience.

How Glycation Affects the Skin

• Healthy collagen fibres are naturally flexible, strong, and resilient, allowing the skin to remain firm, lifted, and structurally supported;
• When glycation occurs, these fibres become increasingly rigid and brittle;
• This reduces their ability to flex and function properly, weakening the skin’s structural framework over time;
• As a result, the skin gradually loses elasticity, firmness, and bounce, contributing to sagging, skin laxity, deeper lines, and a loss of youthful facial definition.

Why Glycation Accelerates Visible Ageing

• Unlike oxidation, which damages the skin through external and internal stress, glycation directly alters the physical structure of collagen itself;
• This means the skin does not simply experience temporary stress—it undergoes structural degeneration;
• Over time, glycated collagen becomes harder for the body to repair or replace, accelerating long-term deterioration of the skin’s support network;
• This makes glycation one of the most significant contributors to visible structural ageing and collagen degeneration.

The Relationship Between Glycation and Other Ageing Processes

• Glycation does not occur in isolation;
• Oxidative stress accelerates glycation by increasing the internal instability that contributes to Advanced Glycation End Product formation;
• At the same time, regenerative decline reduces the skin’s ability to repair glycated and damaged collagen effectively;
• Together, these three biological drivers work simultaneously to accelerate skin ageing and structural decline.

Why Glycation Must Be Addressed

• Because glycation contributes directly to collagen degeneration and structural weakening, addressing it is essential in any comprehensive anti-ageing strategy;
• Preventing and reducing glycation helps preserve collagen quality, maintain elasticity, and protect the skin’s structural framework over time;
• Supporting glycation defence is therefore critical for maintaining firmer, smoother, stronger, and more youthful-looking skin.

Targeted Glycation Treatment

• Because glycation contributes directly to collagen degeneration and structural weakening, effectively addressing it requires a comprehensive approach that supports the skin both externally and internally;
• Dermoceutique addresses glycation through targeted topical skincare and advanced internal supplementation—providing a complete inside-out approach to glycation defence.

Powered by Advanced Polyphenols (Key Active Ingredients)

Resveratrol

A potent antioxidant polyphenol that helps neutralise free radicals and protect the skin against oxidative damage.

EGCG

A green tea-derived polyphenol known for its antioxidant and calming properties, helping to reduce oxidative stress and support skin protection.

Ferulic Acid

A powerful antioxidant that helps reinforce the effectiveness of other antioxidants while enhancing the skin’s defence against environmental stressors.

• The Polyphenol Defense Serum serves as the first protective step in the Dermoceutique anti-glycation protocol;
• By reducing oxidative stress, it helps minimise one of the key processes that accelerates glycation—creating a more stable environment for the skin and preparing it for targeted glycation defence through the Anti-Glycation Serum;
• Together, these formulations work in synergy to support collagen preservation, protect structural proteins, and maintain long-term skin resilience.

Application

• Apply each morning to clean skin before moisturiser and sunscreen;
• Follow with daily SPF protection to further minimise oxidative damage and environmental stress throughout the day;
• In the evening, apply the Anti-Glycation Serum as the second step in the Dermoceutique anti-glycation system to support collagen preservation and protect against sugar-induced structural damage;

Powered by Advanced Anti-Glycation Actives

Carnosine

• Carnosine is a targeted anti-glycation compound that helps prevent sugars from binding to collagen and elastin, reducing the formation of Advanced Glycation End Products (A.G.E.s);
• Glycation weakens and stiffens collagen fibres, causing the skin to lose elasticity, firmness, and structural support over time;
• By helping limit this process, carnosine supports the preservation of firmer, smoother, and more resilient skin—helping reduce the visible effects of skin ageing and maintain a youthful complexion.

Resveratrol

• Resveratrol is a potent antioxidant polyphenol that helps protect the skin’s structural proteins against oxidative stress;
• Oxidative stress accelerates skin ageing by contributing to collagen degradation, dullness, fine lines, and loss of firmness;
• By helping defend the skin against this damage, resveratrol supports collagen health, promotes brighter and healthier-looking skin, and helps maintain a firmer, more youthful appearance.

Pterostilbene

• Pterostilbene is an advanced polyphenol known for its enhanced stability and potency, helping to reinforce antioxidant defence and support long-term collagen preservation;
• By helping protect collagen from environmental and oxidative damage, it supports the maintenance of skin strength, elasticity, and structural integrity;
• This contributes to smoother skin texture, improved firmness, and the long-term preservation of youthful-looking skin.

Key Benefits

• Following the Polyphenol Defense Serum, it provides targeted protection against sugar-induced structural damage—helping to defend collagen and elastin where glycation directly impacts the skin and contributes to visible structural ageing;
• Helps defend collagen and elastin against sugar-induced damage, preserving the skin’s foundational support network and reducing the structural decline associated with ageing;
• Supports the preservation of firmness, elasticity, and structural integrity, helping the skin maintain a lifted, youthful, and resilient appearance;
• Helps reduce the effects of glycation-related stiffening within the skin, which can contribute to rigidity, sagging, and reduced skin flexibility over time;
• Maintains flexibility and resilience of structural proteins over time, supporting the skin’s ability to remain supple, firm, and resistant to premature aging;
• Contributes to smoother, firmer, and more structurally supported skin, helping improve the overall appearance of skin quality and youthful definition;
• Together, these formulations work in synergy to support collagen preservation, maintain structural integrity, and provide a comprehensive approach to glycation defence—helping protect against one of the key biological drivers of visible skin ageing.

Application

• Apply each evening to clean skin after cleansing;
• For optimal results, use after the Polyphenol Defense Serum has been applied;
• Use consistently to support long-term preservation of skin structure and resilience.

Internal Support

Nutricosmetics & Nutraceuticals

• Glycation occurs both within the skin and throughout the body;
• It is not driven only by external sugars—internal metabolic processes also contribute to the formation of Advanced Glycation End Products (A.G.E.s), which affect collagen systemically, including in the skin.

How Topical & Internal Support Work Together

• Topical formulations do not act on “external sugars” alone;
• They work directly within the skin, helping to protect collagen and elastin from glycation-related damage at the tissue level;
• This supports the skin’s structure by preserving the integrity, flexibility, and function of its structural proteins;
• Internal support addresses glycation at its source—within the body;
• As glycation processes occur systemically, reducing them internally helps limit the formation of damaging molecules that also affect the skin;
• This translates directly to improved preservation of collagen and overall skin structure over time.

Integrated Approach

• Dermoceutique combines targeted topical care with internal support to address glycation both locally and systemically;
• Topical formulations help protect and preserve collagen within the skin;
• Internal support helps reduce the processes that lead to glycation throughout the body, including the skin.

Topical + Internal Synergy

• The Polyphenol Defense Serum helps reduce oxidative stress, which accelerates glycation;
• The Anti-Glycation Serum protects collagen directly within the skin;
• The Anti-Glycation Capsules help reduce glycation processes internally;
• Together, they support the preservation of skin structure more effectively than any single approach alone.

Outcome

• By addressing glycation both at the skin level and within the body, Dermoceutique supports the maintenance of collagen integrity, helping to preserve firmness, elasticity, and long-term skin resilience.

Powered by Advanced Internal Support Actives

• While topical formulations help protect the skin externally, glycation is not limited to the surface alone;
• Glycation is a systemic biological process that occurs throughout the body, where sugars bind to proteins and form harmful molecules known as Advanced Glycation End Products (A.G.E.s);
• These molecules accumulate over time and contribute to the weakening, stiffening, and deformation of structural proteins, including collagen and elastin;
• As glycation progresses internally, collagen throughout the body—including within the skin—gradually loses its flexibility, strength, and structural integrity;
• The A.G.E. Defense Capsules are designed to support the reduction of glycation processes from within, complementing topical skincare by addressing the internal pathways that contribute to structural aging;
• By supporting glycation defence internally, they help reinforce collagen preservation and contribute to the maintenance of firmer, stronger, and more resilient skin over time.

Carnosine

• Carnosine helps reduce the binding of sugars to proteins, supporting the prevention of Advanced Glycation End Product formation;
• Advanced Glycation End Products (A.G.E.s) contribute to the stiffening, weakening, and degeneration of collagen fibres over time;
• By helping to limit their formation, carnosine supports the preservation of collagen integrity—helping maintain skin firmness, elasticity, and structural resilience.

Benfotiamine

• Benfotiamine supports metabolic pathways involved in sugar processing, helping to limit glycation-related stress within the body;
• Excess glycation-related stress contributes to the internal formation of damaging compounds that accelerate collagen degeneration and structural ageing;
• By helping regulate these processes, benfotiamine supports the long-term preservation of skin structure and firmness.

Polyphenols

Polyphenols help reduce oxidative processes associated with glycation, supporting overall cellular protection and resilience.
Oxidative stress accelerates glycation and contributes to the breakdown of structural proteins within the skin.
By helping reduce oxidative pressure internally, polyphenols support collagen preservation and contribute to healthier, stronger, and more resilient skin over time.

Key Benefits

• Supports glycation defence from within by helping reduce internal biological processes that contribute to collagen damage and premature skin aging;
• Helps reduce internal processes that contribute to collagen degeneration, supporting the preservation of skin firmness, elasticity, and structural strength over time;
• Assists in limiting the formation of Advanced Glycation End Products (A.G.E.s), harmful molecules that stiffen and weaken collagen—contributing to sagging, reduced elasticity, and visible structural aging of the skin;
• Supports preservation of collagen integrity and structural resilience, helping maintain smoother, firmer, and more resilient skin;
• Reinforces the effects of topical glycation defence by complementing skincare with internal support, helping protect the skin both externally and from within;
• Helps maintain firmer, stronger, and more structurally resilient skin over time by supporting long-term collagen preservation from within;
• By helping preserve collagen quality and structural integrity, it contributes to a firmer, smoother, and more lifted appearance—supporting a more youthful-looking complexion over time.

Complete Glycation Defense System

• The A.G.E. Defense Capsules complete the Dermoceutique glycation defence protocol
• While the Polyphenol Defense Serum reduces oxidative stress and the Anti-Glycation Serum protects collagen at the skin level, the A.G.E. Defense Capsules help support glycation defence internally;
• Together, this inside-out approach provides a comprehensive strategy for preserving skin structure and defending against glycation-related ageing

Application

• Take daily as directed to support glycation defence and collagen preservation from within;
• For optimal results, use alongside the Polyphenol Defense Serum and Anti-Glycation Serum as part of the complete Dermoceutique glycation defence protocol

Nutraceutical and Nutricosmetic Support

• Dermoceutique Advanced Glycation End Product Defense Capsules are formulated as both a nutraceutical and a nutricosmetic—combining internal biological support with targeted aesthetic benefits for the skin;
• As a nutraceutical, the formulation is designed to support internal biological processes involved in glycation defence, helping reduce the formation of harmful Advanced Glycation End Products (A.G.E.s) throughout the body;
• By supporting these internal pathways, it helps protect structural proteins such as collagen from sugar-related degeneration and glycation-induced damage;
• As a nutricosmetic, the formulation is specifically developed to translate these internal benefits into visible skin support—helping preserve firmness, elasticity, structural resilience, and overall skin quality over time;
• By helping maintain collagen integrity from within, the capsules support a firmer, smoother, and more youthful-looking complexion